Cathedral Valletta was built in 1573-1577 gg and consecrated in honor of the patron Saint of the knights of Saint John – Saint John the Baptist. The façade of the Cathedral is decorated with a balcony, supported by two Corinthian columns. Here Grand masters read his proclamation. Crowning the facade of two small square towers, the spires of which were removed during the Second world war.

The interior of the temple is decorated with reliefs in the form of grape bunches. Baroque ceiling was painted by the artist Mattia pretty. In the floor of the Cathedral are 365 tombstones mosaic work made of marble of different colors. Chapel Cathedral divided by country; here have found their final resting place of the knights of Saint John.

The Cathedral has a Museum of one painting – canvases of Caravaggio's "the beheading of John the Baptist."