Gallery of old and new masters in the Palace of Sermage is one of the parts of the Foundation of the museums of varaždin, based in the Palace. Also here is the archaeological Department. The building was built in the XVII century. It is the epitome of the Baroque style. Until the XVIII century the Palace belonged to the family of Baron Francis Prusinski, and later the building passed into the possession of the family Sermage.

An exhibition entitled "Contemporary Croatian art gallery" was opened in the Old city in 1939 and was the beginning of a future extensive collection of the best examples of visual art in Croatia. At the origins of the collection are works by Stephen Leitner and Marusevich. In 1947, the Museum moved to the Palace of Sermage and became known as the "Gallery of old and new masters", the name it bears today.

The gallery introduces visitors to more than three thousand works, a significant number of the old masters, they are the basis of the exhibition. Today, the Museum exhibits 61 picture painted in the XV-XIX centuries. The most valuable are the works of Dutch masters of the XVII and XVIII centuries. Portrait painting of the XIX century is represented by works of local artists-naturalists: A. Moiseeva, M. Brodnik, M. Building. There are also works by contemporary Croatian painters and sculptors.

All works are divided into collections: about 1,000 works executed in various techniques of painting during the time period from XV to XX century; nearly 300 drawings are part of a special collection, which includes works of XIX-XX centuries. Worth noting is the collection of unique prints created since the beginning of the XVII and XX century. There is also a collection of 48 works of Milenko Stancich, which includes sketches, paintings and prints by the master, as well as documents and photographs related to the life of this talented artist.

In addition to the permanent exhibition of the local Department regularly organizes temporary exhibitions that demonstrate the stages of development not only of certain artists, but art in Croatia in General.