St. Mark's Cathedral is located on the square named after the poet Cacica. It is built in Baroque style. The construction of the Cathedral began in 1700, on the initiative of Bishop Nicholas Bijakovici, but was only completed in 1756. That's when it was consecrated Bishop Steven Blaskovich.

The facade of the Church looks to the southwest, so the towers of the Cathedral can be seen from almost any point in the city. On the right side of the entrance are the relics of St. Clement, patron of the city of Makarska and its diocese. The Saint's relics were brought from the Roman catacombs in 1725, and since then are in the Cathedral, attracting pilgrims.

The left side is the altar of the rosary. The wooden altar of the virgin and child on the hand made by masters of the Byzantine school. This altar according to local residents was made during the plague of 1815. The second altar is in honor of the Holy cross.

The Cathedral was badly damaged during a strong earthquake of 1962, and after reconstruction in the decoration of the Church were made some changes. After the earthquake were also damaged choirs, and in 1970, the Cathedral was fitted with a new body of work of the Slovenian company "GenCo".