In the center of Heraklion town, on the 25th of August is another important historical monument is the Church of Saint Titus. The name of the Church was in honor of the patron Saint Titus, who in the first century ad preached on the island of Christianity. Saint Titus was a disciple of the Apostle Paul and the first Bishop of Crete.

In 961 the Emperor Nicephorus Phocas brought Arabs from Crete, resulting in the island was again under the wing of the powerful Byzantine Empire. Then was built the Cathedral of St. Titus, to revive the Christian faith and traditions of Crete, dilapidated after the conquest by the Muslims. The first Church, dedicated to St. Titus was in the ancient city of Gortys (Gortyna), which was the first capital of Roman Crete, but it was destroyed by an earthquake. The island's capital was moved to Candia (Heraklion), and relics of the old temple (the relics of St. Titus, the miraculous icon of the virgin Mary, etc.) transported to the new abode.

In the Byzantine period, the Church was the residence of the Orthodox Archbishop of Crete (during the Arab domination it also housed a Christian Church). During Venetian rule in the same building is the Cathedral of the Catholic Archbishop. During the period when Crete was ruled by the Turks, the Church was converted into a mosque. All of the major relics of the Cathedral were taken to Venice by General Morosini before the invasion of the Turks in the city.

Big earthquake of 1856 destroyed the building. In 1872 the Church was rebuilt on the old Foundation under the leadership of the Ottoman architect Athanasios Mosassa. In 1920-ies, when the last Muslims left Heraklion, the Church was re-consecrated as an Orthodox Church. He was then reconstructed the Church and the minaret was replaced by a bell tower. In 1956, the relics of St. Titus were returned to Heraklion and now preserved in the Cathedral of St. Titus.