The Palazzo della Cancelleria Palace in the Renaissance style in Rome, situated between the present Corso Vittorio Emanuele II and Campo dei Fiori in the heart of Parione. Built between 1489 and 1513 m years by an unknown architect for cardinal Raffaele Riario, the camerlengo of the Roman Catholic Church (one of the Supreme court positions to the Holy see). The Palazzo is considered to be the earliest in Rome a Palace built in the Renaissance style. Today the building is occupied by the Apostolic office, and it itself is part of the territory of the Vatican city state, i.e. it belongs to Italy. In this capacity, nominated as a UNESCO world Cultural Heritage site by UNESCO.

As mentioned above, the Palazzo was built for cardinal Raffaele Riario, nephew of the powerful Pope Sixtus IV. According to the legend, the money for the construction of the Palace were won in one night gambling. It is believed that over the building worked Bramante and Andrea Bregno, although reliable information about it has survived. In 1517 the newly built Palace was captured by the first Pope from the Medici family – Leo X, who had not forgotten about the participation of Sixtus IV in the so-called Pazzi conspiracy, when ruling in Florence the Medici wanted to change the Della Rovere family.

The Palazzo della Cancelleria was the first Palace in Rome, built in the Renaissance style from the base. Its long facade as if imbibing a small Basilica of San Lorenzo in Damaso, located to the right. This Church of the 5th century, like many others in Rome, stands on the site of the ancient mitreola (a pagan temple). During excavations of the late 20th century it was discovered the Foundation of the temple, built in 4-5th centuries Pope Damasius I, it is considered one of the most important early Christian churches in the town. Nearby was a cemetery, the ruins of which were also found.

Travertine (tufa) for the construction of the Palazzo was brought from the ruins of the ancient Theater of Pompey, and 44 Egyptian granite columns in the courtyard that had once been part of a covered gallery theatre. Interestingly, the very form of the patio resembles the courtyard of the Palazzo Ducale in Urbino.

Landmark Palazzo della Cancelleria wall is a fresco by Giorgio Vasari, which he wrote in 100 days than not forgot to boast in front of Michelangelo.