Nikolo-ensure the Church is a functioning Orthodox Church, which is one of the iconic sights of Irkutsk. This is the last stone structure of the city, built in the classical style.

The initiators of the construction of the temple were residents of Glazkovo villages, previously attached to the parish of Trinity Church, located in the centre of Irkutsk, beyond the river. In the off-season, due to the lack of crossing of the river Angara, the parishioners could not attend the temple. That is why the residents decided to go to Irkutsk Spiritual Consistory with the application to give permission for the erection of their own Church.

The construction of the temple was blessed by the Archbishop of Irkutsk Eusebius, however, he put before the congregation, two conditions: the first was that the Church was stone, and the second is that the temple must be built according to the project, which will adopt the Irkutsk provincial construction Commission. According to some, the temple project was developed by the Irkutsk architect Belevskim. Funds for the construction of the Church was allocated a local merchant J. S. Malkov.

In September 1859, a solemn consecration of the temple in honor of St. Nicholas and innocent. After four years with the Northern part of the Church was built on the assumption chapel, which was consecrated in 1866 he Erected a chapel on the donations of the "local resident" I. S. Mogilev. Also installed a carved gilded iconostasis and bought new utensils.

In 1934 Nikolo-ensure the Church was closed. The Church by this time was practically inactive – not the clergy. Remaining Holy vessels were transferred to the railway club. Was demolished bell tower, crowning part and added a second floor. After the building was placed under the jurisdiction of the Irkutsk exhibition chains.

In 1990 the Church was returned to Irkutsk diocese, which has started restoration works that lasted until 2003.