The Basilica of Saint Anthony is a ten minute walk from the centre of Melnik. The Church is located on the territory of the cultural-historical architectural reserve "Melnik".

The temple was built in 1765. In shape Basilica built of stones and bricks, bonded with a special solution, resembles a large ship. The facade with four asymmetrically arranged Windows and the Central entrance is the widest part of the building, which gradually narrows. Inside the Church is richly decorated with frescoes: flowers, cherubim, Seraphim, angels, etc. of Exceptional value are the iconostasis and the icons (especially the "mother of God" and "Holy mother of God").

This is the only in Bulgaria and on the Balkan Peninsula Church, named after St. Anthony the Great. In Christianity, this Saint is the patron Saint of the mentally ill. According to legend, the temple has miraculous properties. All patients with mental disorders, which were conducted in the temple one night, healed the Saint Anthony. The Church preserved the rod with iron chain, which was intended for violent mentally ill.

At present Basilica is a monument of culture of national significance.