The Church of St. Nicholas is the third Orthodox Church of Ruse – after temples of the Holy Trinity and St. George.

Initially the temple was built as a Greek chapel, but after the Balkan wars of 1912-1913, when the number of Greeks in the city began to decrease, departed the Bulgarian Church (1 June 1914). A few years later in Rousse (as in Bulgaria) there are many refugees from the civil war that followed the Bolshevik revolution in Russia. Then the Church gave for the religious needs of Russian immigrants. The Russians brought into the Church, their icons and books, and conducted their services in parallel with the activities of the Bulgarian Orthodox Church. Thus, the Church of St. Nicholas became known among the inhabitants of the town of Ruse as "the Russian Church".

In the 1990s began the process of painting of the temple, which lasted ten years. Now the Church is decorated with paintings by the artists Asana Yankova, Ivo Gotovskogo and Peynaud Panova. Not so long ago to the building of a bell tower was added, which is a 240-pound bell.

In 1973 the Church of St. Nicholas because of its interesting destiny and connection with the dramatic history of Bulgaria was declared a monument of culture.