The Byzantine Museum of the Greek city of Ioannina (capital of Epirus) is located in one of the buildings of the Citadel, known as the Acropolis of Its Kale. The Central section was built in the 1960s, and initially functioned as a Royal pavilion. The Museum was opened to the public in 1995.

The Museum presents collections of early Christian and Byzantine sculptures, unique artifacts from excavations in Arta, architectural fragments, ceramics, ancient manuscripts, first editions of printed books, post-Byzantine icons and much more.

Among the most valuable and interesting exhibits of the Byzantine Museum is worth noting marble fragment of the iconostasis from the Glick, decorated with relief images of birds on the front side and a floral pattern on the bottom surface (end of 12th – beginning of 13th century), the first printed edition of the "Review" Simplicia to the writings of Aristotle (year 1499, Venice, typography N.Vlastos), manuscript of the gospel from the monastery Molyvdoskepasto (1575 year) and the icon by the famous Cretan painter Theodoros Poulakis (second half of 17th century). No less interesting and a clay icon from the Eastern pediment of the Church of St. Basil in Arta (14th century), fragment of a fresco from the Church of the blessed virgin Mary from Voulgarelis (1281 year), wall painting from a wealthy home in Ioannina depicting the legendary battle Multistage bridge (Alexandros Demiris, 19th century), the left chancel door of the Church of St. Nicholas from Perama (15th century) and the icon depicting St. Catherine. Excellent collection of silverware exhibited in a separate building from the 19th century.

Today, the Byzantine Museum is one of the most interesting and popular attractions of Ioannina. Unique relics stored in the Museum are of high historical and artistic value.