Local history Museum in the Bayou was opened in 1919. The basis for the collection of local Amateur archaeologists and local historians, the most outstanding personality among whom was I. P. Krylov. In the pre-revolutionary period I. P. Krylov together with historian A. P. Vershinsky published in an Oxbow of the whole of Tver governorate local history magazine called "Tverskaya antiquity".

In the beginning of its existence, the Museum was housed in the former Holy Dormition monastery, the Abbot's building. During the great Patriotic war Museum collection do not wait too long to take out, and it was almost completely destroyed. Died of priceless manuscripts, objects, books. Since 1975, Staritsa local history Museum housed in the building of the presentation Church of the Holy Dormition monastery. In 1977, Staritsa, the Museum acquired the status of a branch of the Tver United Museum.

In 2008, due to the fact that the building Vvedensky Church was transferred to Tver diocese and was included in the total complex of restored Holy Dormition monastery in Staritsa on the Fund of revival of the Holy Dormition monastery to Museum a new building was erected. The Museum is located at the entrance to a city near Ilyinsky temple.

New regional Museum, planning and interiors which fully meet modern requirements, has become the center of education, research, and Patriotic work, which deals with the organization of leisure of the population in different age categories. It also hosts various academic activities.

Employees Staritsky Museum together with the Tver Museum developed and updated numerous excursions, among which a special place is occupied excursions, devoted to the archaeological finds of the Tver region (on the Bayou at the Museum until recently was the main archaeological exhibition United Museum), history Staritsky region from the mid-16th century to 1917 and from 1917 to the present, architecture and the history of the Dormition monastery, architecture and Oxbow history of the city associated with the name of Pushkin.

In the exposition of the Museum tells about the events of the time of Troubles, a native of the Old women – the first Russian Patriarch job, the Abbot of the monastery of the assumption, on the reforms of Catherine II, who approved the plan and the emblem and of the city. In the Museum you can learn about the most important Staritsa crafts: stonecutting, blacksmith, Potter, to see the objects of national life.

Separate thematic complex of the Museum is devoted to the nobility of old women. Here is an exhibition that tells the story of urban life in the 19th-early 20th centuries.: trade, administration, culture, life, education. The true highlight of the show is an urban interior. A separate section in the Museum relates to the period of the great Patriotic war.

Through constant scientific expeditions and activity Staritsa local historians, the Museum and exhibitions are constantly replenished.