Cathedral of the Immaculate Conception, located in the city of Zamboanga on the island of Mindanao, is one of the largest modern cathedrals Asia.

The first Cathedral of the Immaculate Conception, built of wood on a concrete Foundation that once stood near Pershing Square on the place where today is the Zamboanga University. Above its main altar is kept the image of the Immaculate Conception of the virgin Mary, and on both sides of it you can see images of two saints Ignatius Loyola and Francis Xavier. In 1943 during the Second World war, the Cathedral was bombed by Japanese aircraft, and was destroyed.

A new wooden Church building was built in 1956 next to the University of Ateneo de Zamboanga. Earlier this place was a chapel, known as the Jardin de Chino. On the left side of the facade is a sculpture of the Immaculate Conception of the virgin Mary in full growth, and on the right towered belfry. In 1998 the building was demolished because it was seriously damaged by termites.

The current building of a Cathedral in the form of a cross was built from 1998 to 2001. Inside you can see the marble statue of the Immaculate Conception of the virgin Mary, made by the Philippine national artist Napoleon Abueva. Along the side aisles are stained symbolic images of all the bishops of Mindanao from 1910 to 1984. The chapel on the first floor is used for weekday masses. Before it you can see the baptistery with the relics of the blessed virgin Pilarski, patroness of the city. And behind the baptistery is located columbarium with a copy of the "Pieta" by Michelangelo and the paintings of the 12 apostles.